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Canadian Journal of Anesthesia, Vol 19, 445-452, Copyright © 1972 by Canadian Anesthesiologists' Society

Ketamine-Induced Cataleptogenic Effects in the Rabbit: Potentiation and Antagonism

L. AUTHIER M.SC., M.D.1, A. SINDON M.D., C.S.P.Q., F.R.C.P.(C)1, R. CHAPADOS M.D., C.S.P.Q., C.S.C.R.1, and P. P. BARRY M.D., C.S.P.Q., C.S.C.R.1

1 Department of Anaesthesia, Maisonneuve Hospital, Montreal

This is a preliminary study undertaken to establish a technique for the measurement of catalepsy in the rabbit and to apply this technique to the evaluation of substances which are able to modify catalepsy induced by Ketamine. Our premises were based on the hypothetical relationship between experimental catalepsy and drug-induced extrapyramidal reactions. If such a relation exists, in our experimental conditions, Ketamine induced catalepsy in the rabbit was not antagonised by procyclidine, which is known to antagonise extrapyramidal reactions induced by neuroleptic drugs.

Note:

This paper was presented at the Annual Meeting of the Canadian Anaesthetists' Society, July 1971.






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Copyright © 1972 by the Canadian Anesthesiologists' Society.