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Canadian Journal of Anesthesia, Vol 19, 486-490, Copyright © 1972 by Canadian Anesthesiologists' Society

The Dead Space after Addition of Oxygen and Premedication with Narcotics and Belladonna Drugs

K. W. TURNBULL B.A.SC., M.D.1

1 St. Paul's Hospital, Vancouver, British Columbia

Fitteen patients ranging in age from 30 to 64 years and undergoing cardiac surgery were studied preperatively and after premedication to assess the effects of narcotic-belladonna premedication on changes in phusiological dead space (VDphys), when inspired oxygen was varied from 20.95 per cent to 100 per cent. Measurements of arterial blood gases, end-tidal and mixed expired gases showed that there was asignificant increase in dead space/tidal volume ratio (VD/VT) when the inspired oxygen concentration was increased. Combined narcotic and belladonna premedication did not significantly affect VD/VT ratios when the same increase in inspired oxygen occured.

Absolute values of VDphys are increased by high tidal volumes and this should be correlated with the VD/VT changes to aid in the clinical interpretation. It is likely that narcotic-belladonna premedication does not contribute to the increase in dead space which is found in the anaesthetized patient.






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Copyright © 1972 by the Canadian Anesthesiologists' Society.