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Canadian Journal of Anesthesia, Vol 19, 623-633, Copyright © 1972 by Canadian Anesthesiologists' Society

Energy Metabolism and Electrolytes during Thiopentone-Meperidine Anaesthesia in Nobmal Man

EMERSON A. MOFFITT M.D.1, ALAN D. SESSLER M.D.1, RALPH S. GOLDSMITH M.D.1, ROBERT J. RYAN M.D.1, and KAI REHDER M.D.1

1 Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Energy metabolism and electrolyte values were studied in 28 volunteers during general anaesthesia without operation for periods up to 3 hours. Anaesthesia was induced and maintained with a combination of thiopentone sodium, meperidine, and succinylcholine given by intravenous injection. Ventilation was controlled and normal arterial oxygen and carbon dioxide tensions were maintained. Plasma sodium and potassium concentrations did not change but those of magnesium and inorganic phosphate decreased during anaesthesia. Plasma concentrations of total and ionixed calcium, parathyroid hormone, and total protein concentration were unchanged. Blood glucose and plasma insulin concentartions increased from exogenous dextrose but those of fatty acids, ketone bodies, luteinizing hormone, and growth hormone showed no change. General anaesthesia with these nonvolatile agents produced no evidence of a stress response as reflected in energy metablolism.






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Copyright © 1972 by the Canadian Anesthesiologists' Society.