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Canadian Journal of Anesthesia, Vol 2, 191-197, Copyright © 1955 by Canadian Anesthesiologists' Society

A Comparison of the Anti-Emetic Effects of Dimenhydrinate, Promethazine Hydrochloride and Chlorpromazine following Anaesthesia

DOREEN CAPLIN M.D.1 and CODE SMITH M.D.2

1 Clinical Fellow in Anaesthesia, Department of Anaesthesia, Faculty of Medicine, University of Toronto
2 Hospital for Sick Children, Toronto

One hundred and forty-five patients undergoing operation for the correction of squint were studied with respect to the effectiveness of three anti-emetic drugs Dimenhydrinate (40 cases), Promethazine hydrochloride (20 cases), Chlorpromazine (25 cases), and a control group (60 cases).

Chlorpromazine reduced the incidence of vomiters to a significant degree, reduced the frequency of vomiting in cases that did vomit, produced only a slight prolongation in the time of recovery from anaesthesia, and did not decrease the average fluid intake.

Dimenhydrinate reduced the incidence of vomiters and frequency of vomiting to a less marked degree than chlorpromazine, produced a somewhat more prolonged recovery time than chlorpromazine, and did not decrease fluid intake.

Promethazine hydrochloride did not significantly decrease the incidence of cases of vomiting post-operatively, although the frequency of vomiting was decreased. Recovery time was more prolonged than with either of the other drugs and the fluid intake was slightly reduced.

We conclude that, of the three drugs investigated, chlorpromazine is the most effective anti-emetic drug with a minimum of sicle-effects in children undergoing operation for the correction of squint.






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Copyright © 1955 by the Canadian Anesthesiologists' Society.