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Canadian Journal of Anesthesia, Vol 2, 327-339, Copyright © 1955 by Canadian Anesthesiologists' Society

The Use of Largactil in Obstetrics

JOHN I. DAVIES M.D., F.R.C.P.(C), F.F.A.R.C.S.1

1 Department of Anaesthesia, Winnipeg General Hospital, and the University of Manitoba

Largactil 25 mgm. was given intravenously to 100 patients during labour and the results compared with the course of labour m 100 similar cases.

Following the administration of Largactil excellent psychic sedation was usually observed. The patients became relaxed immediately, slept between pains, but could be easily roused. Apprehension was relieved.

The best results were obtained when an analgesic was also used during the first stage of labour. Largactil was used to best advantage when given to primigravidae just before full cervical dilatation and to multigravidae when the cervix was about half dilated. If no analgesic had been given the simultaneous administration of Demerol 25 mgm. intravenously with the Largactil produced better sedation.

For the actual delivery, if general anaesthesia was necessary, the amounts necessary were greatly reduced, Nitrous Oxide-Oxygen being sufficient for most operative deliveries.

Post-partum sedation was required less often.

Vomiting during labour was relieved by Largactil and the incidence of nausea and vomiting after general anaesthesia and delivery was significantly decreased.

No ill effects on mother or child weie observed.

It would appear that Largactil would be useful in premature deliveries as it does not have any apparent naicotizing effect on the baby, and by its use the amounts of analgesics and anaesthetics can be greatly reduced.

Largactil sometimes appears to have a tendency to slow up labour, particularly in grand multiparae and those patients with poor uterme contractions.

In Caesarean section, Largactil combined with light anaesthesia and a muscle relaxant appears to be effective and safe.

It is suggested that Largactil deserves further investigation of its uses in obstetrics.

Note:

Presented at the Western Regional Meeting, Canadian Anaesthetists' Society, Regina, Sask., April 23, 1955.






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Copyright © 1955 by the Canadian Anesthesiologists' Society.