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Canadian Journal of Anesthesia, Vol 2, 340-346, Copyright © 1955 by Canadian Anesthesiologists' Society

Chlorpromazine and Promethazine in Obstetrics

JOHN J. CARROLL M.D.1 and PETER W. HUDSON M.D.1

1 Department of Anaesthesiology, Vancouver Grace Hospital

Two hundred patients were given Chlorpromazine and Demerol intramuscularly during labour. Hypnosis and analgesia were found to be unpredictable. No appreciable alterations were noted m patient's pulse, blood pressure, or foetal heart rate in the normo-tensive patients. The amount of opiates during labour and of anaesthesia during delivery was lessened. Nausea and vomiting were practically absent, and no ill effects on the babies were noted.

Promethazme was given in the same way to 300 patients m labour. A satisfactory sedative dose was reasonably predictable. Hypnosis and analgesia from Demerol were appreciably potentiated by the drug. The labour rooms were noticeably quieter and the patients less concerned about their labour. As with Chlorpromazine, anaesthesia for delivery was decreased and the incidence of nausea and vomiting became remarkably low. The drug appeared to have no depressing or other undesired effect on the baby. It was our impression that Promethazme and Demerol given during labour offer the mother more effective sedation and her baby less harm, than any combination of drugs with which we are acquamted.

Note:

Presented at the Annual Meeting, Canadian Anaesthetists' Society, Toronto, Ontario, June 20, 1955






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Copyright © 1955 by the Canadian Anesthesiologists' Society.