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Canadian Journal of Anesthesia, Vol 21, 139-146, Copyright © 1974 by Canadian Anesthesiologists' Society

The Effect of Pancuronium on Reflex Regulation of Heart Rate in Man

P. C. DUKE M.D., F.R.C.P.(C), G. MITTLER B.SC., and J. G. WADE M.D., F.R.C.P.(C)

We have shown that the baroreflex is partially maintained in patients anaesthetized with methoxyflurane following the administration of pancuronium. Initially heart rate responses are counteracted by the vagolytic effect of pancuronium, which might be explained by a muscarinic and/or ganglionic blocking property of the drug.

Note:

From the Department of Anaesthesia, Health Science Centre (General) Winnipeg and the University of Manitoba.






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Copyright © 1974 by the Canadian Anesthesiologists' Society.