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Canadian Journal of Anesthesia, Vol 21, 147-152, Copyright © 1974 by Canadian Anesthesiologists' Society

The Effect of Pancuronium Bromide on Plasma Norepinephrine and Cortisol Concentrations During Thiamylal Induction

ELEMÉR K. ZSIGMOND M.D.1, AKITOMO MATSUKI M.D.1, SARLA P. KOTHARY M.D.1, ROBERT C. KELSCH M.D.2, and LOUISE VADNAY 2

1 Department of Anaesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan 48104, U.S.A.
2 Department of Paediatrics, University of Michigan Medical Center, Ann Arbor, Michigan 48104, U.S.A.

Effects of pancuronium on free norepinephrine and cortisol concentrations in plasma were investigated in eight elective surgical patients. A dose of 0.09 mg/kg of pancuronium was administered intravenously following thiamylal induction during nitrous oxide-oxygen inhalation and prior to intubation and surgical preparation. No hypoxic or hypercarbic episodes were demonstrated by arterial blood gas studies.

No significant changes from the base line level were observed either in free norepinephrine levels or in plasma cortisol levels for ten minutes following the administration of pancuronium. Although pancuronium did not cause a rise in free norepinephrine concentration in plasma, it counteracted the hypotension usually observed following the intravenous administration of thiamylal. Heart rate and blood pressure, however, were not significantly increased.






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Copyright © 1974 by the Canadian Anesthesiologists' Society.