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Canadian Journal of Anesthesia, Vol 21, 153-158, Copyright © 1974 by Canadian Anesthesiologists' Society

Convulsions Induced by Local Anaesthetic: Time Course of Diazepam Prophylaxis

RUDOLPH H. DE JONG M.D.1 and JAMES E. HEAVNER D.V.M., PH.D.1

1 Departments of Anaesthesiology and Pharmacology and the Anaesthesia Research Center, University of Washington School of Medicine, mailstop RN-10, Seattle, WA 98195, U.S.A.

The time course of diazepam prophylaxis of convulsions induced by local anaesthetic was gauged by dose-response assays in 12 cats. Curves relating seizure incidence to intravenous lidocaine dose yielded the median convulsant dose (CD50) of lidocaine for each of seven post-diazepam time periods.

The control CD50 for lidocaine was 7.5 mg/kg. Fifteen minutes after 0.25 mg/kg diazepam (I.M.) the lidocaine CD50 already was 187 per cent of control (14.1 mg/kg) and it peaked to 232 per cent (17.4 mg/kg) at 30 minutes after diazepam. Two hours after diazepam the CD50 still remained at nearly double the control value (14.5 mg/kg), and even five hours later was more than one and a half times the control CD50 (11.9 mg/kg). Diazepam protection against convulsions induced by local anaesthetic begins soon after intramuscular injection and lasts at lasts five hours.






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Copyright © 1974 by the Canadian Anesthesiologists' Society.