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Canadian Journal of Anesthesia, Vol 21, 315-320, Copyright © 1974 by Canadian Anesthesiologists' Society

The Effect of Pancuronium Bromide on Plasma Nor-Epinephrine Concentrations during Ketamine Induction

AKITOMO MATSUKI M.D.1, ELEMÉR K. ZSIGMOND M.D.1, ROBERT C. KELSCH M.D.2, SARLA P. KOTHARY M.D.1, and LOUISE VADNAY 2

1 Department of Anaesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.
2 Department of Paediatrics, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.

Ketamine 2.0 mg/kg alone with nitrous oxide-oxygen inhalation caused a rise in blood pressure, pulse rate and free nor-epinephrine levels in plasma in twelve elective surgical patients. Contrary to expectations, the combination of ketamine with pancuronium during nitrous oxide-oxygen inhalation caused no rise in nor-epinephrine in plasma and reduced the rise in arterial blood pressure and pulse rate. No intubation, surgical preparation, or positional changes were allowed. No hypoxia or hypercarbia was demonstrated by the blood gas studies. The mechanism of this blocking effect of pancuronium on ketamine-induced norepinephrine rise await clarification by further laboratory and clinical experiments. The combination of ketamine with pancuronium, can therefore be safely employed in patients in whom marked circulatory changes should be avoided.






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Copyright © 1974 by the Canadian Anesthesiologists' Society.