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Canadian Journal of Anesthesia, Vol 21, 461-466, Copyright © 1974 by Canadian Anesthesiologists' Society
1 Department of Anaesthesia, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania
In six healthy unpremedicated, adult male volunteers (mean age 23 years), cardiac index (CI)(mean = 2.91 ± S.E. 0.12 L/min/kg), alveolar-arterial oxygen tension difference (AaDo2) (mean = 38 ± S.E. 13 torr), and percent pulmonary venous admixture (Qs/Qc%) (mean = 2.94 ± S.E. 0.51%) were measured breathing 100 per cent oxygen (Phase 1). Anaesthesia was then induced either with thiopentone (3 mg/kg) (Phase 2) or halothane:oxygen (Phase 3) and maintained in both cases with oxygen:halothane for one hour with mechanical ventilation. Halothane was then discontinued until awakening and anaesthesia reinduced with the agent not previously used, and measurements of Phases 2 and 3 repeated after another one hour. Temperature, PaCo2, ventilation, cardiac output, and blood pressure were unchanged. The efficiency of oxygen exchange in the lungs following a thiopentone induction was significantly better than that following a halothane: oxygen induction. After thiopentone induction AaDo2 (mean = 38 ± S.E. 13 torr) and Q·s/Q·c (mean = 2.99 ± S.E. 1.05%) were unchanged from the awake values, while following halothane:oxygen induction AaDo2 (mean = 48 ± S.E. 12 torr) and Q·s/Q·c (mean = 3.81 ± 1.2 torr) were significantly (P > 0.05) increased.
Note:
Dr. Marshall is a Professor.
Dr. Hoffman's present address is Department of Anaesthesia, Letterman General Hospital, San Francisco, California.
Dr. Neufeld is an Assistant Professor.
Dr. Colton's present address is Department of Anaesthesia, University of Connecticut Medical Center, Hartford, Connecticut.
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