CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LEVESQUE, P. R.
Right arrow Articles by SHIMOSATO, S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by LEVESQUE, P. R.
Right arrow Articles by SHIMOSATO, S.

Canadian Journal of Anesthesia, Vol 21, 580-585, Copyright © 1974 by Canadian Anesthesiologists' Society

Circulatory Effects of Enflurane in Normocarbic Human Volunteers

PAUL R. LEVESQUE M.D.1, VERONICA NANAGAS M.D.1, CAROLYN SHANKS B.A.1, and SHIRO SHIMOSATO M.D.1

1 Department of Anesthesiology, Tufts University School of Medicine and New England Medical Center Hospitals, Boston, Mass. 02111

The circulatory effects of enflurane were studied in ten unmedicated normocarbic volunteers during anaesthesia over a period of 90 minutes or more. Cardiac output did not change significantly during anaesthesia at a mean alveolar anaesthetic concentration of 2.3 volumes per cent and ranging from 1.8 to 3.2. Systolic, diastolic and mean arterial pressures decreased significantly, as did total peripheral resistance. The heart rate increased in all cases. Cardiac output was maintained primarily by an increased heart rate, which compensated for the decreased total peripheral resistance. At recovery, all haemodynamic parameters except heart rate returned to control levels. Minimal change in cardiac output during enflurane anaesthesia in man may be related to the combination of decreased mean arterial pressure and increased heart rate.

Note:

Recipient of Research Career Development Award, 5-K04-HE42, 406-03, United States Public Health Service.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1974 by the Canadian Anesthesiologists' Society.