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Canadian Journal of Anesthesia, Vol 22, 125-137, Copyright © 1975 by Canadian Anesthesiologists' Society

Distribution of Kidney Blood Flow: A Comparison of Methoxyflurane and Halothane Effects as Measured by Heated Thermocouple

KENNETH LEIGHTON 1 and CAROLINE BRUCE 1

1 Departments of Anaesthesia and Pharmacology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada, V6T 1W5

Heated thermocouples have already proved their worth in assessing tissue perfusion. The principle involved is that of heat clearance. This technique has been employed to investigate the distribution of renal blood flow with particular reference to outer and inner cortical perfusion. The effect of varying the depth of anaesthesia with methoxyflurance and halothane upon the intrarenel distribution of blood flow has been studied. Methoxyflurance (but not halothane) appears to promote a reduction on outer cortical perfusion and a relative increase in inner cortical perfusion. This may be significant in the production of nephrotoxicity by mithoxyflurance, since it may lead to a more prolonged tubular contact with the toxic products of methoxyflurance metablism.

Note:

This work was supported by a grant-in-aid of research awarded by the British Columbia Heart Foundation.






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Copyright © 1975 by the Canadian Anesthesiologists' Society.