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Canadian Journal of Anesthesia, Vol 22, 358-369, Copyright © 1975 by Canadian Anesthesiologists' Society

Central Nervous System Effects of Bupivacaine

W. MURRAY ROBINSON 1 and LEONARD C. JENKINS 1

1 Department of Anaesthesia Experimental Laboratory within the Department of Pharmacology, Faculty of Medicine, University of British Columbia

The central nervous system and concurrent cardiovascular effects of bupivacaine infusion were studied in cats. It was possible to block cortical E.E.G. desynchronization resulting from a sensory stimulus with bupivacaine. The earliest subcortical change that occurred was rhythmic activity in the amygdala and later in the hippocampus. Occasionally, this activity appeared simultaneously in both these sites. Diazepam pretreatment raised the seizure threshold of bupivacaine. Diazepam was also effective in terminating established seizure activity resulting from bupivacaine. All animals pretreated with diazepam (Valium®) or diazepam solvent developed cardiac dysrhythmias during bupivacaine infusion. The possible clinical significance of the interaction of bupivacaine and diazepam solvent is considered.






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Copyright © 1975 by the Canadian Anesthesiologists' Society.