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Canadian Journal of Anesthesia, Vol 22, 486-494, Copyright © 1975 by Canadian Anesthesiologists' Society

Response to Hypercapnia Under Ketamine Anaesthesia

MAGDI G. SOLIMAN 1, G. FRED BRINDLE 1, and GUSTAVO KUSTER 1

1 Department of Anaesthesia, Centre Hospitalier Universitaire, Sherbrooke, Quebec

The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased. This respiratory stimulation was most probably due to a direct eifect of the drug on the medullary respiratory neurones. This effect was not modified by preanaesthetic medication pentobarbitone 5 mg/kg or morphine 0.1 mg/kg.

Catecholamine response to hypercapnia was essentially the same as that reported by hypercapnic dogs anaesthetized with thiopentone.






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Copyright © 1975 by the Canadian Anesthesiologists' Society.