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Canadian Journal of Anesthesia, Vol 22, 673-679, Copyright © 1975 by Canadian Anesthesiologists' Society

Cardiac Output Response to Altered Acid-Base Status during Diethyl Ether Anaesthesia

JOSEPH O. SODIPO 1, DO-CHIL LEE 1, and LUCIEN E. MORRIS 1

1 University of Toronto, Aneathesia Research Laboratoy at St.Micheal's Hospital, Toronto

The effects of acid-base changes on cardiac output during diethyl ether anaesthesia were studied in 25 mongrel dogs prepared by surgically implanting a plastic encased non-ferrous core electromagnetic probe on the ascending aorta. The findings are:

(1) Metabolic acidaemia produced only slight decrease in cardiac output but a more marked fall became evident with decreasing pH.

(2) Respiratory acidaemia led to a slight rise in cardiac output.

(3) Respiratory alkalaemia decreased cardiac output.

(4) Metabolic alkalaemia also produced a decline in cardiac output.






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Copyright © 1975 by the Canadian Anesthesiologists' Society.