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Canadian Journal of Anesthesia, Vol 22, 680-686, Copyright © 1975 by Canadian Anesthesiologists' Society

The Myocardial Effects of Pancuronium

P. C. DUKE 1, H. FUNG 2, and J. GARTNER 1

1 Departments of Anesthesiology, Medicine and Pharmacology, University of Manitoba
2 Departments of Anesthesiology, Health Sciences Centre-General and Faculty of Medicine, University of Manitoba

The effect of pancuronium on myocardial contractility was studied in three different animal preparations. Pancuronium produced no change in isometric contraction of rabbit atrial or cat papillary muscle but displaced the acetylcholine dose-response curve to the right in the papillary muscle preparations, verifying a muscarinic blocking effect of this drug. In atropinized dogs in vivo pancuronium produced no significant change in the cardiovascular parameters studied. These studies show that pancuronium exerts its cardiovascular effects primarily by blocking muscarinic receptors in the heart.






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Copyright © 1975 by the Canadian Anesthesiologists' Society.