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Canadian Journal of Anesthesia, Vol 23, 71-79, Copyright © 1976 by Canadian Anesthesiologists' Society

A Comparison of the Effects of Halothane and Other Anaesthetic Agents on Hepato-Cellular Function in Patients Submitted to Elective Operations

B. KALOW 1, E. ROGOMAN 1, and F. H. SIMS 1

1 Departments of Anaesthesia and Clinical Biochemistry, Women's College Hospital and University of Toronto, Toronto, Canada M5S 1B2

In an attempt to gather objective evidence of possible hepato-cellular toxicity of the halogenated anaesthetics halothane and methoxyflurane pre-operative and post-operative enzyme estimations were done on patients admitted for elective operations. The series of approximately 500 cases included 160 patients submitted to cholecystectomy, an operation associated with a high percentage of detectable alteration of hepatocellular function in the post-operative period. There was no significant difference between the groups of patients receiving halothane, methoxyflurane, or nitrous oxide and oxygen with analgesic supplement. The magnitude of the increased post-operative enzyme activity and the post-operative temperature elevation were not significantly different in the three groups studied.






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Copyright © 1976 by the Canadian Anesthesiologists' Society.