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Canadian Journal of Anesthesia, Vol 23, 176-184, Copyright © 1976 by Canadian Anesthesiologists' Society

Dobutamine and General Anaesthesia: A Study of the Response of Arterial Pressure, Heart Rate and Renal Blood Flow

KENNETH M. LEIGHTON 1 and CAROLINE BRUCE 1

1 Departments of Anaesthesia and Pharmacology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada, V6T 1W5

The effects of dobutamine, a new catecholamine, have been studied during anaesthesia with halothane, halothane and nitrous oxide and alphaprodine. Renal blood flow is increased by dobutamine as are mean arterial pressure and heart rate. The increase in rate is less marked during alphaprodine anaesthesia than when halothane is administered. Dobutamine may prove a useful agent in the management of acute circulatory failure but it is capable of inducing dysrhythmias under the conditions of these experiments.

Note:
Supported by a grant-in-aid of research awarded by the British Columbia Heart Foundation.






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Copyright © 1976 by the Canadian Anesthesiologists' Society.