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Canadian Journal of Anesthesia, Vol 23, 252-262, Copyright © 1976 by Canadian Anesthesiologists' Society

The Effects of Althesin and Thiopentone on Sympathetic and Baroreflex Activity

J. E. MACKENZIE 1, J. C. McGRATH 1, J.-P. TÉTRAULT 1, and R. A. MILLAR 1

1 University Department of Anaesthesia, Royal Infirmary, Glasgow, G4 OSF, Scotland

In decerebrate rabbits which were mechanically ventilated, both Althesin and thiopentone depressed preganglionic sympathetic activity and arterial pressure. Conduction through central baroreceptor pathways, tested by depressor nerve stimulation, showed a selective inhibition of the heart rate response by both agents. Effects were similar with Althesin injection in animals which were lightly anaesthetized with pentobarbitone. Depression of the arterial pressure and sympathetic components of the baroreceptor reflex was apparent only with high doses.

Note:

Present addresses: Université de Sherbrooke, P.Q.

Memorial University, St. John's, Newfoundland.






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Copyright © 1976 by the Canadian Anesthesiologists' Society.