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Canadian Journal of Anesthesia, Vol 23, 290-295, Copyright © 1976 by Canadian Anesthesiologists' Society

Radioimmunoassay of Antidiuretic Hormone during Morphine Anaesthesia

DANIEL M. PHILBIN 1, NORMAN E. WILSON 1, JOHN SOKOLOSKI 1, and CECIL COGGINS 1

1 Harvard Anaesthesia Research Laboratories and the Cardiac Anaesthesia Group and the Department of Medicine at the Massachusetts General Hospital, Boston, Massachusetts 02114

Address correspondence to Daniel M. Philbin, M.D., Department of Anesthesia, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114.

The effect of morphine anaesthesia on plasma antidiuretic hormone levels was studied in seven adult patients. Measurements of ADH showed no significant change with morphine and 50 per cent nitrous oxide. Significant elevation occurred with surgical stimulation as previously reported. Changes in urine flow with high doses of morphine are then not ADH related.






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Copyright © 1976 by the Canadian Anesthesiologists' Society.