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Canadian Journal of Anesthesia, Vol 23, 624-635, Copyright © 1976 by Canadian Anesthesiologists' Society

The Adenosine Triphosphate (ATP) Depletion Test: Comparison with the Caffeine Contracture Test as a Method of Diagnosing Malignant Hyperthermia Susceptibility

BEVERLEY A. BRITT 1, LASZLO ENDRENYI 2, WERNER KALOW 2, and PEARL L. PETERS 2

1 Departments of Anaesthesia and Pharmacology, University of Toronto, Toronto, Ontario
2 Department of Pharmacology, University of Toronto, Toronto, Ontario

The adenosine triphosphate (ATP depletion ratio, which is the ratio

[ATP] in skeletal muscle equilibrated with carbogen and 4% halothane for 30 minutes/[ATP] in skeletal muscle equilibrated with carbogen alone for 30 minutes

is less than normal in most but not in all rigid MHS patients. The ratio is normal in non-rigid MHS patients. This diagnostic tool is, therefore, useful in the diagnosis of rigid MH. It is not, however, such a sensitive diagnostic parameter as the caffeine contracture test.






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Copyright © 1976 by the Canadian Anesthesiologists' Society.