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Canadian Journal of Anesthesia, Vol 24, 103-109, Copyright © 1977 by Canadian Anesthesiologists' Society

Porcine Malignant Hyperthermia: Role of Skeletal Muscle in Increased Oxygen Consumption

GERALD A. GRONERT 1, JAMES J. A. HEFFRON 2, JAMES H. MILDE , and RICHARD A. THEYE 3

1 Mayo Medical School, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901
2 Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901
3 Mayo Medical School, Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

During malignant hyperthermia (MH) induced by halothane and succinylcholine, oxygen consumption (V·o2) of whole body, muscle and the splanchnic area was calculated from measurements of blood flow and arteriovenous oxygen content difference. Caudal body blood flow was isolated and measured (six animals) for determination of average muscle V·o2 in the hind limbs, buttocks, and flanks. The increase in muscle V·o2 was extrapolated to total skeletal muscle and compared with the increase in whole body V·o2 (same six animals). The average increase in V·o2 for both total muscle and whole body during the period of maximum increase was about 6 ml O2/min/kg body weight. Splanchnic V·o2 (four animals) tended to decrease during MH. The data support the hypothesis that the metabolic changes in MH are due to a disorder of skeletal muscle and that the increase in whole body V·o2 is due to the increase in muscle V·o2.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.