CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ABOU-MADI, M. N.
Right arrow Articles by YACOUB, J. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ABOU-MADI, M. N.
Right arrow Articles by YACOUB, J. M.

Canadian Journal of Anesthesia, Vol 24, 12-19, Copyright © 1977 by Canadian Anesthesiologists' Society

Cardiovascular Reactions to Laryngoscopy and Tracheal Intubation Following Small and Large Intravenous Doses of Lidocaine

MOUNIR N. ABOU-MADI 1, HUGO KESZLER 1, and JOSEPH M. YACOUB 1

1 McGill University; Department of Anaesthesia, Queen Mary Veterans' Hospital, 4565 Queen Mary Road, Montreal, Quebec, Canada, H3W 1W5

The efficacy of intravenously administered lidocaine 0.75 mg/kg and 1.5 mg/kg to protect against cardiovascular reactions associated with laryngoscopy and tracheal intubation was studied in two comparable groups of ten patients and compared with a similar control group of ten patients given only saline. Following laryngoscopy and tracheal intubation, the 1.5 mg/kg dose afforded complete protection against cardiac arrhythmias of all types. The smaller dose was ineffectual in this respect. While the larger dose caused borderline protection against hypertension and tachycardia, the smaller dose prevented only the rise in systolic blood pressure. Possible mechanisms to account for these observations are discussed. These include a direct myocardial depressant effect, a central stimulant effect, a peripheral vasodilating effect and finally an effect on synaptic transmission.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1977 by the Canadian Anesthesiologists' Society.