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Canadian Journal of Anesthesia, Vol 24, 35-38, Copyright © 1977 by Canadian Anesthesiologists' Society

Clinical Trial of Etomidate

Preliminary Observations on a New Non-Barbiturate Induction Agent

C. E. FAMEWO 1 and C. O. ODUGBESAN 1

1 Department of Anaesthesia, University of Ibadan, and University College Hospital, Ibadan, Nigeria

This is a preliminary report of our clinical experience with etomidate, a new intravenous non-barbiturate anaesthetic agent. Thirty-two patients undergoing minor surgical procedures were anaesthetized, induction being with etomidate 0.3 mg/kg body weight. Induction was fast and smooth. Twenty-eight per cent of the patients complained of pain at site of injection but the pain disappeared on flushing with water for injection. Following etomidate injection, 37.5 per cent of patients developed myoclonic movements which were usually mild and self-limiting. We were impressed by the relative stability of the cardiovascular and respiratory systems. Etomidate looks promising and further work is in progress on other aspects of this drug.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.