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Canadian Journal of Anesthesia, Vol 24, 361-370, Copyright © 1977 by Canadian Anesthesiologists' Society

Foetal Deterioration Following Thiopentone-Nitrous Oxide Anaesthesia in the Pregnant Ewe

R. J. PALAHNIUK M.D.1 and M. CUMMING R.N., B.Sc.1

1 Departments of Anaesthesia and Obstetrics and Gynaecology, Health Sciences Centre and University of Manitoba, Winnipeg, Manitoba

Address reprint requests to: Dr. R.J. Palahniuk, Department of Anaesthesia, Health Science Centre, Winnipeg, Manitoba R3E 0Z3.

Six pregnant sheep were chronically prepared with indwelling catheters in maternal and foetal vessels and a flow probe around a maternal uterine artery. They were anaesthetized the following day with thiopentone and nitrous oxide (70 per cent)-oxygen (30 per cent) maintenance with tracheal intubation. Maternal uterine blood flow fell about 20 per cent following induction of anaesthesia. This resulted from uterine vasoconstriction which, in turn, probably resulted from maternal catecholamine release during light anaesthesia. The foetus in utero developed a mixed metabolic and respiratory acidosis and a fall in oxygen saturation. The possibility that light maternal anaesthesia increases rather than decreases neonatal depression is discussed.

Note:

Supported by a grant from the Medical Research Council of Canada.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.