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Canadian Journal of Anesthesia, Vol 24, 433-444, Copyright © 1977 by Canadian Anesthesiologists' Society

Reduction of Hypoxic Pulmonary Vasoconstriction by Diethyl Ether in the Isolated Perfused Cat Lung: The Effect of Acidosis and Alkalosis

J. B. HURTIG M.D., F.R.C.P.(C)1, A. R. TAIT B.Sc.1, and M. K. SYKES M.B., B.Chir., F.F.A.R.C.S.1

1 Department of Anaesthetics, Royal Postgraduate Medical School, London, England

Hypoxic pulmonary vasoconstriction is a protective mechanism diverting pulmonary blood flow away from hypoxic areas toward more optimally oxygenated lung units. Venous admixture is reduced and arterial oxygenation improved. Hypoxic pulmonary vasoconstriction was demonstrated during acidosis, alkalosis and normal pH in the isolated perfused cat lung under conditions of constant flow and constant left atrial and airway pressures. Two per cent diethyl ether markedly reduced hypoxic vasoconstriction under all acid-base conditions, the hypoxic pressor response returning after wash-out of diethyl ether. Modification of hypoxic pulmonary vasoconstriction during acid-base disturbances and possible implications of concurrent anaesthetic administration are discussed.

Note:

Present Address: Department of Anaesthesia, 4th Floor Link, Ottawa Civic Hospital and The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, Canada, K1Y 4E9.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.