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Canadian Journal of Anesthesia, Vol 24, 445-451, Copyright © 1977 by Canadian Anesthesiologists' Society

The Direct Effects of Circulating Lidocaine on Uterine Blood Flow and Foetal Well-Being in the Pregnant Ewe

DIANE BIEHL M.D.1, SOL M. SHNIDER M.D.1, GERSHON LEVINSON M.D.1, and KEITH CALLENDER M.D.1

1 Departments of Anesthesia, Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143

Reprint requests to Sol M. Shnider, M.D.

We infused lidocaine intravenously into 13 pregant ewes at a rate sufficient to maintain plasma levels between 2-4 µgm/ml, which are those commonly seen with regional anaesthesia. These levels did not change maternal blood pressure, pulse rate, cardiac output, stroke volume, total peripheral resistance, uterine blood flow or intra-amniotic pressure. Foetal blood pressure and pulse rate remained stable as did both maternal and foetal blood gases and acid-base values.

Note:

Dr. Biehl's current address is: Department of Anaesthesia, St. Boniface Hospital, Winnipeg, Manitoba R2H 2A6.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.