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Canadian Journal of Anesthesia, Vol 24, 459-467, Copyright © 1977 by Canadian Anesthesiologists' Society

Meperidine - Halothane Interaction in Dogs

E. P. STEFFEY V.M.D., Ph.D.1, R. MARTUCCI B.S., M.S.2, D. HOWLAND B.S.1, J. H. ASLING M.D.2, J. H. EISELE M.D.2, and C. HIRSCH B.A.2

1 Department of Veterinary Surgery, University of California, Davis, CA 95616, U.S.A.
2 Department of Medical Anesthesiology, University of California, Davis, CA 95616, U.S.A.

We studied the interaction of meperidine and halothane in 24 unmedicated, spontaneously breathing dogs. Intramuscular (i.m.) injections of meperidine, 2.75 mg/kg, 5.5 mg/kg and 11.0 mg/kg reduced the minimal alveolar concentration (MAC) of halothane required for anaesthesia. The magnitude and duration of MAC depression were dose related. Plasma meperidine concentrations following an i.m. injection of 2.75 mg/kg were lower in the awake, unsedated dogs than in the dogs anaesthetized with halothane.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.