CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by YANG, E.
Right arrow Articles by LEE, C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by YANG, E.
Right arrow Articles by LEE, C.

Canadian Journal of Anesthesia, Vol 24, 468-474, Copyright © 1977 by Canadian Anesthesiologists' Society

Neuromuscular Block by Circulating D-Tubocurarine Residue following Uptake and Distribution

ELAINE YANG M.D.1 and CHINGMUH LEE M.D.1

1 Department of Anesthesiology, UCLA School of Medicine, Los Angeles, CA. 90024

Communications to: Chingmuh Lee, M.D., Associate Professor, Department of Anesthesiology, UCLA School of Medicine, Los Angeles, CA. 90024

Serum concentration of d-tubocurarine decreases rapidly after intravenous injection because of uptake and distribution. The circulating residue of an ED 50 dose of d-tubocurarine five minutes after injection will produce no block in a previously unexposed neuromuscular junction. To produce a 50 per cent block with the circulating d-tubocurarine residue in a previously unexposed neuromuscular junction requires an initial injection of 2.5 x ED 50 dose. Five minutes after a dose 5 to 6 times the ED 50, the plasma d-tubocurarine residue is sufficient to produce a total block.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1977 by the Canadian Anesthesiologists' Society.