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Canadian Journal of Anesthesia, Vol 24, 505-513, Copyright © 1977 by Canadian Anesthesiologists' Society

The Effects of Propanidid on Arterial Pressure, Pulse Rate, Preganglionic Sympathetic Activity and Barostatic Reflexes in the Cat

KAJ WISBORG M.D.1, SANGUAN SAPTHAVICHAIKUL M.D.1, and PER SKOVSTED M.D.1

1 Department of Anaesthesiology, Hahnemann Medical College and Hospital of Philadelphia, Philadelphia, Pennsylvania 19102, U.S.A. and Department of Anaesthesia, Rigshospitalet (University Hospital), Blegdamsvej 9, 2100 Copenhagen, Denmark

We have studied the effects of propanidid on preganglionic cervical sympathetic nervous activity, arterial pressure, pulse rate and barostatic reflexes of the cat. Normal, hypertensive, baroreceptor denervated and decerebrate animals with sectioned vagal nerves were studied. On the basis of our findings it is concluded that propanidid exerts its depressant action on the cardiovascular system directly. Central circulatory control mechanisms are essentially unaffected. The depression of arterial pressure caused by propanidid is moderated by two compensatory mechanisms: normal barostatic reflexes causing an increased sympathetic tone in response to hypotension and a vagolytic action of propanidid.

Note:

1 Kaj Wisborg, M.D., visiting Assistant Professor of Anaesthesia.

2 Sanguan Sapthavichaikul, M.D., Senior Instructor of Anaesthesia.

3 Per Skovsted, M.D., Assistant Professor of Anaesthesia. Present Address: Department of Anaesthesia, Rigshospitalet Blegdamsvej 9, 2100 Copenhagen, Denmark.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.