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Canadian Journal of Anesthesia, Vol 24, 565-570, Copyright © 1977 by Canadian Anesthesiologists' Society

The Effects of Etomidate on Arterial Pressure, Pulse Rate and Preganglionic Sympathetic Activity in Cats

PER SKOVSTED M.D.1 and SANGUAN SAPTHAVICHAIKUL M.D.2

1 Department of Anaesthesiology, Hahnemann Medical College and Hospital of Philadelphia, Pennsylvania, 19102, U.S.A.
2 Department of Anaesthesia, Rigshospitalet (State University Hospital), Blegdamsvej 9, 2100 Copenhagen, Denmark

We have studied the effects of etomidate on preganglionic cervical sympathetic activity, arterial pressure, and pulse rate.

Normal and baroreceptor-denervated animals were studied. On the basis of findings it is concluded that etomidate exerts a minimal direct depressant action on the cariovascular system. A profound depression of sympathetic tone was observed in spite of unaffected arterial pressure. Etomidate was also shown to possess a mild vagolytic action.

Note:

Per Skovsted, M.D., Anaesthetist in Chief, Rigshospitalet.

Sanguan Sapthavichaikul, M.D., Senior Instructor of Anaesthesia.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.