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Canadian Journal of Anesthesia, Vol 24, 637-640, Copyright © 1977 by Canadian Anesthesiologists' Society

Sodium Nitroprusside-Induced Hypotension and Renal Blood Flow

K. M. LEIGHTON 1, C. BRUCE 1, and B. A. MACLEOD 1

1 Departments of Anaesthesia and Pharmacology, Faculty of Medicine, The University of British Columbia, Vancouver, B.C. V6T 1W5

Hypotension produced by sodium nitroprusside during halothane anaesthesia in a series of experiments in dogs was accompanied by the maintenance of renal blood flow. Renal blood flow was maintained at levels of systemic pressure at which flow is customarily reduced in man and experimental animals. The significance of this observation is the possibility that sodium nitroprusside has a protective effect on the kidney, not only in states of deliberate hypotension, but in other low flow states where renal perfusion and function may be compromised.

Note:

Supported by a grant-in-aid of research from The British Columbia Heart Foundation.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.