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Canadian Journal of Anesthesia, Vol 24, 707-711, Copyright © 1977 by Canadian Anesthesiologists' Society

Physostigmine Reversal of Postoperative Somnolence

GARY E. HILL M.D.1, THEODORE H. STANLEY M.D.1, and CRAIG R. SENTKER B.S.1

1 Department of Anaesthesiology, the University of Utah College of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132

The effects of physostigmine on reversal of post-operative somnolence following general anaesthesia were evaluated in 187 patients. Significant reversal of anaesthetic-induced post-operative somnolence was observed in those patients receiving physostigmine when compared to a control group. These results suggest that general anaesthesia with halothane may be included in those situations where central nervous system depression may be reversed by administration of physostigmine. Cholinergic side-effects observed with physostigmine administration were minimal.






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Copyright © 1977 by the Canadian Anesthesiologists' Society.