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Canadian Journal of Anesthesia, Vol 25, 18-21, Copyright © 1978 by Canadian Anesthesiologists' Society
1 Department of Anesthesiology, University of Utah College of Medicine, 50 North Medical Drive, Salt Lake City, Utah, 84132
Changes in whole body oxygen consumption due to bolus infusions of fentanyl and thiopentone given during "balanced anaesthesia" have been examined in 17 patients. It has been shown that fentanyl causes an average decrease in oxygen consumption of 4.9, 8.4, and 5.2 per cent at 5, 10 and 15 minutes after its infusion. Thiopentone causes an average decrease of 7.0, 8.8, and 1.9 percent at 5, 10 and 15 minutes after infusion. It is believed that the effects of fentanyl and thiopentone on oxygen consumption are caused mainly by decreases in cerebral and myocardial oxygen consumption.
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