CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BROCK-UTNE, J. G.
Right arrow Articles by DOWNING, J. W.
Right arrow Search for Related Content
PubMed
Right arrow Articles by BROCK-UTNE, J. G.
Right arrow Articles by DOWNING, J. W.

Canadian Journal of Anesthesia, Vol 25, 144-146, Copyright © 1978 by Canadian Anesthesiologists' Society

The Effect of Glycopyrrolate (Robinul) on the Lower Oesophageal Sphincter

J. G. BROCK-UTNE F.F.A.(S.A.)1, J. RUBIN F.F.A.R.C.S.(Eng.)1, S. WELMAN M.B.1, G. E. DIMOPOULOS F.R.C.S.(Eng.)1, M. G. MOSHAL M.R.C.P.(Lond.)1, and J. W. DOWNING F.F.A.R.C.S.(Eng.)1

1 Departments of Anaesthetics, Obstetrics and Gynaecology, Gastrointestinal Unit and Surgery. University of Natal, P.O.Box 17039, Congella 4013, Durban, South Africa

Regurgitation and inhalation of acid gastric content, with resultant chemical pneumonitis remains a common cause of death during anaesthesia.

The effects of intravenous glycopyrrolate 0.3 mg on the lower oesophageal sphincter tone was studied in normal human subjects. Glycopyrrolate decreased lower oesophageal sphincter pressure by 0.88 kPa (p < 0.005).

This finding is of clinical importance in the pre-operative preparation of patients presenting for emergency surgery. A drug which decreases lower oesophageal sphincter tone would presumably increase the hazard of gastro-oesophageal reflux and pulmonary aspiration of acid gastric content.

Note:

Present address: Department of Anaesthesia, Stanford University Medical Center, Stanford, California 94305, U.S.A.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1978 by the Canadian Anesthesiologists' Society.