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Canadian Journal of Anesthesia, Vol 25, 181-190, Copyright © 1978 by Canadian Anesthesiologists' Society

The Effect of Ethanol on the Ventilatory Responses Mediated by the Peripheral Chemoreceptors in Man

J. DUFFIN Ph.D.1, E. R. JACOBSON 1, and E. C. ORSINI 1

1 Departments of Anaesthesia and Physiology, Faculty of Medicine, University of Toronto

Address correspondence to: Dr. J. Duffin, Department of Physiology, Medical Sciences Building, University of Toronto, Toronto, Canada, M5S 1A8.

The ventilatory responses mediated by the central and peripheral chemoreceptors were separately assessed in eight healthy volunteers before and after the oral ingestion of ethanol in a dose of 0.75 ml/kg. No significant depression of the central response was observed, but a significant depression of the peripheral response was observed at 25 and 95 minutes after the consumption of ethanol. The peripheral chemoreceptor stimulus was the simultaneous increase of hypoxia and hypercapnia and this novel method is described.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.