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Canadian Journal of Anesthesia, Vol 25, 211-214, Copyright © 1978 by Canadian Anesthesiologists' Society

Comparison of two Benzodiazepines for Anaesthesia Induction: Midazolam and Diazepam

J. G. REVES M.D.1, GUENTER CORSSEN M.D.1, and CLIFFORD HOLCOMB M.D.1

1 Department of Anaesthesiology, University of Alabama Medical Center, Birmingham, Alabama 35294

Ro 21-3981 is a newly synthesized water soluble benzodiazepine derivative. Its pharmacological properties are similar to diazepam. This investigation was designed to establish the effective induction dosage of Ro 21-3981 and to compare it with diazepam for induction of anaesthesia. The ED50 for Ro 21-3981 induction is 0.15 mg/kg and ED100 is 0.2 mg/kg. Ro 21-3981 is one and one-half times as potent as diazepam (0.3 mg/kg) and more rapid in action. There is significantly less pain on injection with Ro 21-3981 as compared to diazepam. Cardiovascular stability and apnoea were observed with both drugs. Ro 21-3981 is a promising anaesthetic induction drug that merits further human study.

Note:

Presented in part at the Annual Meeting of the American Society of Anaesthesiologists at New Orleans, October 1977.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.