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Canadian Journal of Anesthesia, Vol 25, 215-217, Copyright © 1978 by Canadian Anesthesiologists' Society

The Uptake and Excretion of Nitrous Oxide in the Newborn

D. J. STEWARD M.B., F.R.C.P.(C)1 and R. E. CREIGHTON M.D., F.R.C.P.(C)1

1 Department of Anaesthesia, The Hospital for Sick Children, and University of Toronto, Ontario, Canada

Address requests for reprints to: Dr. D.J. Steward, Chief of Anaesthesia, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G IX8

In the newborn, the uptake of nitrous oxide into the alveolus is very rapid, as is the fall in alveolar levels following withdrawal of the agent.

During recovery relatively large volumes of nitrous oxide are excreted in the first minute, after which the excretion rate rapidly declines, most of the gas having been eliminated.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.