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Canadian Journal of Anesthesia, Vol 25, 291-296, Copyright © 1978 by Canadian Anesthesiologists' Society

Effects of Certain Antibiotics on Isometric Contractions of Isolated Rat Heart Muscle

YOUNG-ZIN SOHN M.D.1 and RONALD L. KATZ M.D.1

1 Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California, 90024

The direct effects of potassium-penicillin-G, kanamycin, streptomycin and chloramphenicol on isometric contraction of isolated rat heart muscle were examined. Potassium-penicillin-G did not depress myocardial contractility but rather increased it. Those increases are not due to penicillin itself but due to a small amount of K+ in potassium-penicillin-G.

Kanamycin and streptomycin did show not only direct myocardial depressant effects but concentration-dependent depressions. The depression produced by kanamycin could be restored to normal by adding Ca++ to the bath solution.

Chloramphenicol did not show any significant concentration-dependent depression in our studies.

We conclude that it is important to be aware of the potential depression of cardiac function by antibiotics, particularly in patients who have diminished cardiac reserve and who are undergoing surgical procedures under anesthesia which may also depress cardiac function.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.