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Canadian Journal of Anesthesia, Vol 25, 307-311, Copyright © 1978 by Canadian Anesthesiologists' Society

The Effect of Halothane Anaesthesia on Liver Regeneration

VASILIOS PRATILAS M.D.1, MARGARET G. PRATILA M.D.1, and JOHN P. BRAMIS M.D.1

1 The Departments of Anesthesiology and Surgery of the Mount Sinai School of Medicine of the City University of New York

The effects of halothane and diethyl ether on the regenerating liver following 70 per cent hepatectomy were studied in Fisher/344 (F) rats. Our aim was to discover whether halothane administered repeatedly and over prolonged periods could influence the liver regenerative process or hepatocyte function. We also wished to know if the effects of halothane differed from those of diethyl ether.

We found: 1. Prolonged halothane or diethyl ether anaesthesia did not inhibit liver mitotic activity, even if administered repeatedly. 2. The effects of halothane and diethyl ether on liver cell division were identical. 3. With reference to liver regeneration, halothane is as safe as diethyl ether when administered during extensive hepatectomy.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.