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Canadian Journal of Anesthesia, Vol 25, 319-322, Copyright © 1978 by Canadian Anesthesiologists' Society

Pressure Enhancement of the Depressant Effect of Halothane on Cilial Beat

W.D. B. POPE M.D.1, A. J. JONES 1, M. J. HALSEY 1, and J. F. NUNN M.D., Ph.D., F.F.A.R.C.S.1

1 The Division of Anaesthesia, Clinical Research Centre, Watford Road, Harrow, Middlesex HAI 3UJ, England

Reprint requests to W.D.B. Pope, M.D.

In order to test the applicability of the critical volume hypothesis of anaesthetic action to the side effects of anaesthesia, we have studied the pressure-anaesthetic interactions on cilial beat. The swimming speed of Tetrahymena pyriformis was determined at one and 137 atmospheres with to 4 per cent halothane. The pressure and anaesthetic effects were synergistic with the halothane dose-response curve being shifted to the left and increased in slope at the high pressure, although high pressure alone had no significant effect. These results are contrary to the predictions of the critical volume hypothesis and appear to demarcate the narcotic effect of anaesthetics from the type of molecular interaction which is concerned in the effect on cilial beat.

Note:

Dr. Pope's current address is: Department of Anaesthesia, University of Manitoba, Health Sciences Centre, 700 William Ave., Winnipeg. R3E 0Z3.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.