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Canadian Journal of Anesthesia, Vol 25, 323-328, Copyright © 1978 by Canadian Anesthesiologists' Society

Effects of Halothane on the Pharmacokinetics of Lidocaine in Digitalis-Toxic Dogs

JAMES R. BOYCE , FRANK W. CERVENKO , and FREDERICK J. WRIGHT

Address reprint requests to Dr. J.R. Boyce, Elba General Hospital, Elba, Alabama, U.S.A.

Following the production of digitalis toxicity in dogs as manifested by ventricular tachycardia, the pharmacokinetics of lidocaine treatment of the arrhythmia were determined during pentobarbitone anaesthesia and pentobarbitone-halothane anaesthesia. The elimination rate constants, {beta} and Ke, and the biological half life T1/2{beta} were statistically significantly increased during halothane anaesthesia. The volume of distribution was unchanged. The results indicate that the therapeutic loading dose of lidocaine need not be altered during halothane anaesthesia but if a constant infusion is used, the rate of infusion would have to be decreased four fold to avoid toxic plasma levels of lidocaine.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.