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Canadian Journal of Anesthesia, Vol 25, 366-372, Copyright © 1978 by Canadian Anesthesiologists' Society

Hypoxic Ventilatory Responses during Thiopentone Sedation and Anaesthesia in Man

R. L. KNILL M.D., F.R.C.P.(C)1, S. BRIGHT M.D.1, and P. MANNINEN M.D.1

1 Department of Anaesthesia, University Hospital, University of Western Ontario, London, Canada

Address reprint requests to Dr. R.L. Knill, Department of Anaesthesia, P.O. Box 5339, Postal Stn. A, London, Ontario. N6A 5A5.

We have assessed the impact of thiopentone on the hypoxic ventilatory reflex, and on the responses to carbon dioxide and doxapram. Thiopentone sedation did not detectably alter any of these aspects of ventilatory control. Thiopentone anaesthesia reduced ventilation and the ventilatory responses to hypoxia, carbon dioxide and doxapram, all approximately in parallel. We conclude that, in contrast to halothane, thiopentone does not selectively reduce the ventilatory response to hypoxia. During light thiopentone anaesthesia, a reasonably brisk hypoxic response is present.






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Copyright © 1978 by the Canadian Anesthesiologists' Society.