CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BRITT, B. A.
Right arrow Articles by KENT, G. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by BRITT, B. A.
Right arrow Articles by KENT, G. M.

Canadian Journal of Anesthesia, Vol 25, 373-379, Copyright © 1978 by Canadian Anesthesiologists' Society

Perfusion of Malignant Hyperthermia Susceptible and Normal Isolated Pig Livers with Halothane

BEVERLEY A. BRITT M.D., F.R.C.P.(C)1, BARRY SHANDLING M.B., Ch.B., F.R.C.S.(Eng), F.R.C.S.(C), F.A.C.S.2, LASZLO ENDRENYI Ph.D.3, and GERALDINE M. KENT D.V.M., M.Sc.4

1 Department of Anaesthesia, University of Toronto and Department of Pharmacology, University of Toronto; Toronto General Hospital, Toronto, Canada
2 Department of Surgery, University of Toronto; Staff Surgeon, Hospital for Sick Children, Toronto, Canada
3 Department of Pharmacology, University of Toronto and Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Canada
4 Research Institute, Hospital for Sick Children, Toronto, Canada

We have perfused malignant hyperthermia susceptible and normal isolated pig livers with halothane for one hour. The liver temperatures, oxygen and carbon dioxide tensions, the base deficits and lactate concentrations in blood entering and leaving the liver have been measured at the beginning and at the end of the perfusion. Statistical analysis has shown that there are no significant differences in these parameters between the beginning and the end of the perfusion period or between the normal and the malignant hyperthermia susceptible livers. We conclude, therefore, that the livers of malignant hyperthermia susceptible pigs are either normal or else, if abnormal, the abnormalities are sufficiently benign as to be not measurably expressed.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1978 by the Canadian Anesthesiologists' Society.