CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HODGKINSON, R.
Right arrow Articles by WANG, C. N.
Right arrow Search for Related Content
PubMed
Right arrow Articles by HODGKINSON, R.
Right arrow Articles by WANG, C. N.

Canadian Journal of Anesthesia, Vol 25, 405-411, Copyright © 1978 by Canadian Anesthesiologists' Society

Double-Blind Comparison of the Neurobehaviour of Neonates following the Administration of Different Doses of Meperidine to the Mother

ROBERT HODGKINSON M.A., M.D.1, M. BHATT M.D.1, and C. N. WANG M.D.1

1 Obstetrical Anaesthesia Units, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78207, and Albert Einstein College of Medicine, Bronx, New York, 10461

The Early Neonatal Neurobehavioural Scale (E.N.N.S.) tests, first described by Scanlon, et al.1 were administered to 920 neonates on the first and second days of life. Meperidine was not given to 389 mothers, 50 mg was given to 358 mothers and 75 to 150 mg to 173 mothers within four hours of delivery. The delivery was conducted under chloroprocaine epidural anaesthesia in 280, ketamine-nitrous oxide general anaesthesia in 180, thiopentone-nitrous oxide general anaesthesia in 180 and lidocaine pudendal block in 280. All babies were over 2500 grams in weight with an Apgar score of at least 8 at one minute and 10 at five minutes. All were delivered from healthy women 18 to 35 years of age following a normal labour. The evaluator was unaware anaesthetic management, the method of delivery or the perinatal risk factors. There was no significant difference between the mothers and babies in the three meperidine dosage groups for maternal parity, maternal age, birth weight, number of forceps deliveries or duration of labour.

Administration of meperidine was associated with a broad spectrum depression of most items on the E.N.N.S. on both the first and second days of life. The depression was greatest with the highest dose of meperidine. The depression produced by anaesthetic agents and meperidine were additive and the highest scores on this scale were obtained in those babies delivered under chloroprocaine epidural anaesthesia without meperidine.

Note:

Abstract read at the Annual Meeting of the American Society of Anesthesiologists, San Francisco, October 1976.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1978 by the Canadian Anesthesiologists' Society.