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Canadian Journal of Anesthesia, Vol 26, 117-124, Copyright © 1979 by Canadian Anesthesiologists' Society

In Vivo Neutron Activation Analysis for Bone Calcium (INVAA) in Malignant Hyperthermia Susceptible Patients

B. A. BRITT 1, J. E. HARRISON 2, and K. G. McNEILL 3

1 Departments of Anaesthesia and Pharmacology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
2 Department of Medicine, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
3 Departments of Medicine and Physics, University of Toronto, Toronto, Ontario, Canada

Some non-rigid Malignant Hyperthermia Susceptible (MHS) patients have a greater than normal incidence of fractures. Radiologically their long bones are slightly thinner than normal. Excessive numbers of caries because of thin dental enamel may also be present.1

The Malignant Hyperthermic (MH) defect thus appears to involve cells of bone appendages as well as of muscle. We have measured the concentration of calcium in bone by neutron activation analysis and have found it to be reduced in both non-rigid and rigid malignant hyperthermia susceptible patients. The reductions were particularly marked for the non-rigid patients. Bone calcium concentrations were lower in males than in females and in those under 16 and over 60 years of age. This is additional evidence in favour of the hypothesis that malignant hyperthermia is a widespread defect affecting tissues and organs throughout the body.






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Copyright © 1979 by the Canadian Anesthesiologists' Society.