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Canadian Journal of Anesthesia, Vol 26, 164-167, Copyright © 1979 by Canadian Anesthesiologists' Society

Halothane Solubility in Blood during Cardiopulmonary Bypass: The Effect of Haemodilution and Hypothermia

TSUNEO SADA 1, HERBERT T. MACUIRE 2, and J. ANTONIO ALDRETE 3

1 Department of Anesthesiology, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, Japan
2 Department of Anesthesiology, University of Louisville, 323 East Chestnut Street, Louisville, Kentucky 40201, U.S.A.
3 Department of Anesthesiology, University of Colorado, Medical Center, 4200 East Ninth Avenue, Denver, Colorado 80262, U.S.A.

The influence of haemodilution and cooling on the solubility of halothane in blood during cardiopulmonary bypass was studied in six normothermic and six hypothermic patients undergoing open-heart operations. The solubility of halothane in blood was 2.17 at 30° C and 1.34 at 37° C. There was also an increase in the blood/gas partition coefficient of about 8.7 per cent for each degree celsius of temperature fall.

These changes in haemodiluted blood explain the different anaesthetic requirements observed in patients undergoing cardiopulmonary bypass, either at normal temperature or at moderate hypothermia.




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R.-G. Yu, J.-X. Zhou, and J. Liu
Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation
Br. J. Anaesth., March 1, 2001; 86(3): 338 - 344.
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Copyright © 1979 by the Canadian Anesthesiologists' Society.