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Canadian Journal of Anesthesia, Vol 26, 168-172, Copyright © 1979 by Canadian Anesthesiologists' Society

Fentanyl-Oxygen Anaesthesia for Coronary Artery Surgery: Cardiovascular and Antidiuretic Hormone Responses

THEODORE H. STANLEY 1, DANIEL M. PHILBIN 2, and CECIL H. COGGINS 2

1 Department of Anesthesiology, The University of Utah College of Medicine, Salt Lake City, Utah 8413
2 Departments of Anaesthesia and Medicine, The Massachusetts General Hospital and the Harvard Medical School, Boston, Massachusetts 02114

This study demonstrates that larges doses of fentanyl, as the sole anaesthetic with ventilation with oxygen, produces complete anaesthesia and minimal changes in cardiovascular dynamics in patients with coronary artery disease. It also indicates that high dose fentanyl anaesthesia blocks the increases in plasma anti-diuretic hormone and cardiovascular dynamics which are so common with morphine and other anaesthetic techniques during tracheal intubation and surgical stimulation in patients with coronary artery disease. Our findings suggest that fentanyl-oxygen anaesthesia is an attractive technique in patients with coronary artery disease.






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Copyright © 1979 by the Canadian Anesthesiologists' Society.