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Canadian Journal of Anesthesia, Vol 26, 353-360, Copyright © 1979 by Canadian Anesthesiologists' Society

Ventilation and Chemoreflexes During Enflurane Sedation and Anaesthesia in Man

R. L. KNILL M.D., F.R.C.P.(C)., P.H.1, P. H. MANNINEN M.D.1, and J. L. CLEMENT R.N.1

1 Department of Anaesthesia, University Hospital, University of Western Ontario, London, Canada

Address reprint requests to Dr. R.L. Knill, Department of Anaesthesia, University Hospital, 339 Windermere Road, London, Ontario, Canada, N6A 5A5.

Enflurane sedation and anaesthesia in healthy fit subjects reduced ventilation and the response to carbon dioxide, hypoxaemia and a low dose of doxapram, all in a dose-related fashion. Comparing the three chemoreflexes tested, the response to hypoxaemia and doxapram were the more profoundly impaired; they were nearly totally abolished by anaesthesia. These effects of enflurane on chemoreflex activities are qualitatively similar to those previously observed with halothane.






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Copyright © 1979 by the Canadian Anesthesiologists' Society.